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Hormone Pellets

Benefits of Hormone Pellet Therapy

Hormone replacement therapy by pellet implantation has been used with great success in the United States, Europe and Australia since 1938 and found to be superior to other methods of hormone delivery. It is not experimental.   Pellets deliver consistent, physiologic levels of hormones and avoid the fluctuations of hormone levels seen with other methods of delivery. Estrogen delivered by subcutaneous implants maintains the normal ratio of estradiol to estrone.

Hormones delivered by the subcutaneous implants bypass the liver, do not affect clotting factors and do not increase the risk of thrombosis. Bioidentical testosterone delivered subcutaneously by pellets is cardiac protective, unlike oral, synthetic testosterone. Testosterone and estradiol delivered by pellet implantation, does not adversely affect blood pressure, lipid levels, glucose or liver functions.

Pellets are superior to oral and topical hormone therapy with respect to relief of menopausal symptoms. Estradiol and testosterone implants have consistently been shown to improve insomnia, sex drive, libido, hot flashes, palpitations, headaches, irritability, depression, aches, pains, and vaginal dryness.

Hormone replacement therapy with estradiol and testosterone implants is superior to oral and topical (both the patch and gel) hormone replacement therapy for bone density. The pellets not only prevent bone loss but actually increase bone density. There is more data on hormone implants and bone density than any of the bisphosphonates (medication used to treat osteoporosis).

Testosterone implants in women have been shown to improve lethargy, depression, loss of libido, hot flashes without attenuating the beneficial affects of estradiol on cardiac and lipid profiles. Testosterone delivered by subcutaneous pellet implants does not increase the risk of breast cancer as does oral, synthetic methyl-testosterone.

Pellets do not have the same risk of breast cancer as Prempro or synthetic Methyl-testosterone.  In fact, studies show a reduction in the incidence of breast cancer with the implantation of testosterone pellets, with or without estradiol pellets.  Hormone replacement therapy with a 20 mg estradiol pellet has been shown to have a lower risk of breast cancer than patients without hormone replacement therapy.  Even after over 20 years of therapy with hormone implants, the risk of breast cancer is not increased.  In breast cancer survivors, hormone replacement therapy with pellet implantation does not increase the risk of cancer recurrence or death as does estrogens in combination with the synthetic progestins.

Low Side Effects
Hormone replacement therapy with pellet implantation has an extremely low incidence of side effects  and high compliance rate.  It has been shown to be extremely effective in the treatment of migraine headaches. Testosterone replacement therapy in men with subcutaneous implants (pellets) has been shown to be extremely effective, convenient and safe. Furthermore, FDA approval is required for ‘drugs being marketed to the public’.  Pellets, in the United States are compounded and not ‘marketed to the public’. 

FDA approval has nothing to do with the efficacy of therapy or whether a medical treatment is experimental.  Testopel® is FDA approved.  However, it is only available in a 75 mg. dose.   The estradiol and testosterone used in the hormone implants are USP (United States Pharmacopeia) certified. I feel that hormone pellets are safe, effective, and medically the best treatment for my patients suffering from hormonal imbalances. Prevention and treatment of disease with pellet implantation is the best and most cost effective therapy I am able to offer to my patients. The data clearly supports their clinical efficacy and safety.  I invite you to give it a try and start feeling like you did when you were younger!

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